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(2016) found that acute fluoxetine administration in prepubertal female rats resulted in increased estradiol concentrations, whereas subchronic administration led to increased serotonin concentrations in the ovaries, a decrease in the number of ovulations, a greater number of atretic follicles, and oocyte fragmentation

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Because caffeine is also absorbed through the bowel, coffee enemas are not recommended in susceptible people such as children and pregnant women

Full evaluation requires at least six months of consistent use